Pharmaceutical coating.



UNITED STATES PATENT OFFICE.

EUGENE DONARD AND HENRI LABBE, OF PARIS, FRANCE.

PHARMACEUTICAL COATING.

Specification of Letters Patent.

Patented Dec. 17, 1907.

Application filed January 16 1906. Serial Ila 296,439.

Z 0 all whom it may concern;

Be it known that we, EUGENE DONARD and HENRI LABBE, citizens of the Republic of France, and residents of Paris, France, have jointly invented certain new and useful Improvements in Pharmaceutical Coating, of which the following is a specification.

This invention relates to pharmaceutical coating, including coating or varnishing witha material applied directly to an alimentary, medicinal, therapeutical, or like substance; capsules in which the substance is inclosed, or admixture of the coating material with the substance to be protected so as to coat each particle of the substance. The coating Ina- 'terial employed is maizin, and the object is to protect the substance from the influencev of oxygen, moisture and certain liquids of the animal organism.

.The preparation of maizin will be found described in U; S. Patent No. 744,510, dated against the destructive and dissolving agencies above referred to, and more especially in cases when it is desired that the pills or capsules should pass unaltered to and into the intestines.

This invention may be carried out in several Way.- A concentrated solution of the maizin having been prepared in one or other of the above quoted solvents,-it may in some cases be simply mixed with the substances which it is desired to protect, the mixture being then allowed to dry. Or the solution may be used as a varnish, which is applied to and allowed to dry on the surface of the substances to. be protected, as in the case of pills or like solid masses. Or the solution maybe used for the preparation, in a suitable basin, say a tin plate, of a film which is subsequently treated in the usual way, and with the usual apparatus employed in the manufacture of globules or capsules for the administration of medicines in the liquid form.

Havingthus described our invention and the method of carrying it out, we clai1n 1. An envelop consisting of maizin adapted to contain a therapeutical substance and to protect the latter from the action of the liquids of the stomach. I

2. The'herein described process of protecting substances against the injurious effeet of certain agencies to which they are exposed, which consists in first dissolving maizin in an organic liquid solvent, and then inclosing the particles of the substance to be protected in the coating formed by the maiZin thusdissolved.

In witness whereof we have hereunto signed our names this 29th day of December 1905; in the presence of two subscribing Witnesses.

EUGENE DONARD. HENRI LABBE. Witnesses:

JULEs ARMENGAUD, Jeune, HANSON 0. CoxE. 

